Carbamazepine-induced toxic epidermal necrolysis treated with intravenous immunoglobulin and amniotic membrane: A case report

Introduction: Toxic epidermal necrolysis (TEN) is a distinct clinical entity within a spectrum of adverse cutaneous drug reactions. The common causative drugs are anticonvulsants, non-steroidal anti inflammatory drugs, sulfonamides and other antibiotics. Carbamazepine is an important antiepileptic drug used to treat bipolar disorder, seizures and nerve pain such as trigeminal neuralgia and diabetic neuropathy, which is considered to be one cause of TEN. Case report We describe TEN in a 7-year-old Iranian girl with no mucosal involvement treated as an emergency burns case with intravenous Immunoglobulin and amniotic membrane. At the end of the treatment period, there were no scars and good cosmetic results achieved. Conclusion: We conclude that early diagnosis, supportive care and careful monitoring for complications comprise crucial management in TEN. Moreover, using an effective co-adjuvant treatment (amniotic membrane and intravenous immunoglobulin), will improve the skin lesions of TEN totally without scars.